Tissue expression
Cell line expression
Protein structure
ATP6V0C
ATPase H+ transporting V0 subunit cATP6C, ATP6L, ATPL, VATL, Vma3
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]
Top validated antibodies |
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Novus Biologicals | NBP1-59654 | 4 references | Polyclonal |
WB
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antibodies-online | ABIN2844163 | 2 references | Polyclonal |
WB
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St John's Laboratory | STJ118778 | Polyclonal |
WB
ICC
IHC
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Invitrogen Antibodies | PA5-116676 | Polyclonal |
WB
ICC |
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LSBio | LS-B12357 | Polyclonal |
WB
IHC |
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