Tissue expression
Cell line expression
Protein structure

TRAF2

TNF receptor associated factor 2
RNF117, TRAP3 
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]
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869 antibodies from 49 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
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1 antibody
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1 antibody
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2 antibodies
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2 antibodies
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GeneTex
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Boster Biological Technology
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SignalChem
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ProSci
4 antibodies
Acris Antibodies GmbH
16 antibodies
NovoPro Bioscience Inc.
5 antibodies
Antibodies.com
1 antibody
Aviva Systems Biology
6 antibodies
Cell Signaling Technology, Inc
3 antibodies
Enzo Life Sciences
2 antibodies
RabMAbs
5 antibodies
Bethyl Laboratories
2 antibodies
Creative Biolabs
25 antibodies
Abbexa
17 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
United States Biological
94 antibodies
MyBioSource
7 antibodies
Rockland Immunochemicals, Inc.
3 antibodies
Leading Biology
7 antibodies
MilliporeSigma / Merck KGaA
5 antibodies
Abbiotec
1 antibody
Signalway Antibody LLC
1 antibody
RayBiotech, Inc.
5 antibodies
Active Motif
1 antibody
GenWay
6 antibodies
Creative Diagnostics
4 antibodies
EMD Millipore
1 antibody