Tissue expression
Cell line expression
Protein structure

KDM6B

Lysine demethylase 6B
JMJD3, KIAA0346 
The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
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386 antibodies from 34 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
98 antibodies
Invitrogen Antibodies
7 antibodies
Novus Biologicals
27 antibodies
GeneTex
2 antibodies
Biorbyt
29 antibodies
OriGene
8 antibodies
NSJ Bioreagents
6 antibodies
Abgent
4 antibodies
Arigo
1 antibody
Proteintech Group
1 antibody
Boster Biological Technology
2 antibodies
Abnova Corporation
5 antibodies
Acris Antibodies GmbH
7 antibodies
St John's Laboratory
4 antibodies
Aviva Systems Biology
4 antibodies
SignalChem
1 antibody
Cusabio Biotech Co., Ltd
5 antibodies
ProSci
4 antibodies
NovoPro Bioscience Inc.
1 antibody
Wuhan Fine Biotech Co., Ltd.
1 antibody
MyBioSource
9 antibodies
Creative Diagnostics
3 antibodies
R&D Systems
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
United States Biological
50 antibodies
EMD Millipore
2 antibodies
Active Motif
1 antibody
Affinity Biosciences
1 antibody
Cell Signaling Technology, Inc
1 antibody
Absolute Antibody
5 antibodies
Abbexa
7 antibodies
MilliporeSigma / Merck KGaA
4 antibodies
Creative Biolabs
8 antibodies