Tissue expression
Cell line expression
Protein structure

ROBO3

Roundabout guidance receptor 3
FLJ21044, HGPPS, HGPS, RBIG1 
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. [provided by RefSeq, May 2019]
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235 antibodies from 33 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
2 antibodies
Novus Biologicals
7 antibodies
R&D Systems
3 antibodies
Biorbyt
43 antibodies
NovoPro Bioscience Inc.
3 antibodies
FineTest Biotech
2 antibodies
antibodies-online
52 antibodies
Cusabio Biotech Co., Ltd
4 antibodies
Invitrogen Antibodies
14 antibodies
Abnova Corporation
8 antibodies
St John's Laboratory
5 antibodies
Antibodies.com
2 antibodies
Everest Biotech
2 antibodies
OriGene
3 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Boster Biological Technology
1 antibody
Acris Antibodies GmbH
2 antibodies
NSJ Bioreagents
1 antibody
Aviva Systems Biology
4 antibodies
FabGennix
3 antibodies
GeneTex
2 antibodies
Arigo
1 antibody
MyBioSource
7 antibodies
ProSci
2 antibodies
United States Biological
24 antibodies
Abbexa
7 antibodies
Creative Diagnostics
3 antibodies
MilliporeSigma / Merck KGaA
2 antibodies
Leading Biology
2 antibodies
Abgent
2 antibodies
EMD Millipore
1 antibody
Creative Biolabs
1 antibody