ROBO3

gene product
FLJ21044, HGPPS, HGPS, RBIG1
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated. [provided by RefSeq, Dec 2009]
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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
7 antibodies
R&D Systems
3 antibodies
NovoPro Bioscience Inc.
3 antibodies
Proteintech Group
2 antibodies
Abnova Corporation
8 antibodies
antibodies-online
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Antibodies.com
2 antibodies
Everest Biotech
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
LifeSpan BioSciences, Inc.
13 antibodies
Acris Antibodies GmbH
2 antibodies
NSJ Bioreagents
1 antibody
OriGene
3 antibodies
Aviva Systems Biology
4 antibodies
Biorbyt
11 antibodies
FabGennix
3 antibodies
GeneTex
2 antibodies
Arigo
1 antibody
St John's Laboratory
6 antibodies
MyBioSource
7 antibodies
ProSci
2 antibodies
Invitrogen Antibodies
1 antibody
United States Biological
24 antibodies
Creative Diagnostics
2 antibodies
Sigma-Aldrich
2 antibodies
Abgent
2 antibodies
EMD Millipore
1 antibody