H1-4

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

Description

H1.4 linker histone, cluster member

Tissue specificity

Group enriched (bone marrow, brain)

Subcell location

Nuclear speckles

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (26156329 - 26157115)

Ensembl ID

ENSG00000168298  (ver. 103.38)

Orthologs

Mouse H1f4: ENSMUSG00000051627

UniProt

P10412

neXtProt

NX_P10412

Human splice variants
Mouse splice variants

Protein structure