NETO2

This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Description

Neuropilin and tolloid like 2

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Golgi apparatus

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

16 (47077703 - 47143945)

Ensembl ID

ENSG00000171208  (ver. 103.38)

Orthologs

Mouse Neto2: ENSMUSG00000036902

UniProt

Q8NC67

neXtProt

NX_Q8NC67

Human splice variants
Mouse splice variants

Protein structure