CHRM4

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]

Description

Cholinergic receptor muscarinic 4

Tissue specificity

Group enriched (brain, intestine, lymphoid tissue, testis)

Subcell location

Nucleoplasm, Golgi apparatus

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

11 (46385098 - 46386608)

Ensembl ID

ENSG00000180720  (ver. 103.38)

Orthologs

Mouse Chrm4: ENSMUSG00000040495

UniProt

P08173

neXtProt

NX_P08173

Human splice variants
Mouse splice variants

Protein structure