Tissue expression
Cell line expression
Protein structure
HEXA
Hexosaminidase subunit alphaThis gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Top validated antibodies |
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Proteintech Group | 11317-1-AP | 7 references | Polyclonal |
WB
EL
ICC
IHC |
|
antibodies-online | ABIN1105521 | 2 references | Monoclonal |
WB
EL
FC
|
|
LSBio | LS-C669794 | Polyclonal |
WB
EL
ICC
IHC |
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Novus Biologicals | NBP1-74127 | 1 references | Polyclonal |
WB
ICC
IHC
|
|
Invitrogen Antibodies | PA5-112847 | Polyclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider