DNAJB1

This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Description

DnaJ heat shock protein family (Hsp40) member B1

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (14514769 - 14560391)

Ensembl ID

ENSG00000132002  (ver. 103.38)

Orthologs

Mouse Dnajb1: ENSMUSG00000005483

UniProt

P25685

neXtProt

NX_P25685

Human splice variants
Mouse splice variants

Protein structure