MICB

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Description

MHC class I polypeptide-related sequence B

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Nucleoplasm, Golgi apparatus, Plasma membrane

Predicted location

Membrane

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

6 (31494881 - 31511124)

Ensembl ID

ENSG00000204516  (ver. 103.38)

Orthologs

-

UniProt

Q29980

neXtProt

NX_Q29980

Human splice variants

Protein structure