Tissue expression
Cell line expression
Protein structure
FAR1
Fatty acyl-CoA reductase 1FLJ22728, MLSTD2, SDR10E1
The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]
Top validated antibodies |
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Invitrogen Antibodies | PA5-53585 | 1 references | Polyclonal |
WB
ICC
IHC
OA |
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Novus Biologicals | NBP1-89847 | 1 references | Polyclonal |
WB
ICC
IHC
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Atlas Antibodies | HPA017322 | Polyclonal |
WB
ICC
IHC
|
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antibodies-online | ABIN4310529 | Polyclonal |
WB
ICC
IHC
|
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Acris Antibodies GmbH | AP52707PU-N | Polyclonal |
WB
EL
IHC
FC |
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