AGO2

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Description

Argonaute RISC catalytic component 2

Tissue specificity

Low tissue specificity

Subcell location

Cytosol, Cytoplasmic bodies

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8:q24.3 (140520156 - 140635633)

Ensembl ID

ENSG00000123908  (ver. 103.38)

Orthologs

Mouse Ago2: ENSMUSG00000036698

UniProt

Q9UKV8

neXtProt

NX_Q9UKV8

Human splice variants
Mouse splice variants