VPS26A

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Description

VPS26, retromer complex component A

Tissue specificity

Low tissue specificity

Subcell location

Endosomes, Lysosomes

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

10 (69123512 - 69174412)

Ensembl ID

ENSG00000122958  (ver. 103.38)

Orthologs

Mouse Vps26a: ENSMUSG00000020078

UniProt

O75436

neXtProt

NX_O75436

Human splice variants
Mouse splice variants

Protein structure