Tissue expression
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Protein structure

HSD11B2

Hydroxysteroid 11-beta dehydrogenase 2
SDR9C3 
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
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307 antibodies from 31 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
NSJ Bioreagents
2 antibodies
Proteintech Group
1 antibody
antibodies-online
111 antibodies
Invitrogen Antibodies
13 antibodies
Atlas Antibodies
2 antibodies
OriGene
4 antibodies
Acris Antibodies GmbH
2 antibodies
Aviva Systems Biology
2 antibodies
Abgent
2 antibodies
Cusabio Biotech Co., Ltd
7 antibodies
NovoPro Bioscience Inc.
2 antibodies
FineTest Biotech
1 antibody
Novus Biologicals
8 antibodies
Abnova Corporation
6 antibodies
R&D Systems
1 antibody
ProSci
4 antibodies
GeneTex
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Affinity Biosciences
1 antibody
St John's Laboratory
2 antibodies
MyBioSource
4 antibodies
Boster Biological Technology
1 antibody
United States Biological
13 antibodies
Abbexa
11 antibodies
Creative Diagnostics
4 antibodies
Leading Biology
1 antibody
RayBiotech, Inc.
1 antibody
MilliporeSigma / Merck KGaA
5 antibodies
Creative Biolabs
2 antibodies