NOG

gene product
SYM1, SYNS1
The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008]
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Antibodies

 

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471 antibodies from 31 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
R&D Systems
2 antibodies
OriGene
11 antibodies
GeneTex
5 antibodies
Novus Biologicals
29 antibodies
antibodies-online
138 antibodies
LifeSpan BioSciences, Inc.
127 antibodies
NovoPro Bioscience Inc.
3 antibodies
Invitrogen Antibodies
6 antibodies
Proteintech Group
1 antibody
Abnova Corporation
11 antibodies
Arigo
1 antibody
Biorbyt
13 antibodies
St John's Laboratory
4 antibodies
Acris Antibodies GmbH
6 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Affinity Biosciences
1 antibody
RabMAbs
4 antibodies
NSJ Bioreagents
1 antibody
MyBioSource
18 antibodies
Aviva Systems Biology
2 antibodies
Creative Biolabs
4 antibodies
ProSci
2 antibodies
Atlas Antibodies
1 antibody
Creative Diagnostics
2 antibodies
RayBiotech, Inc.
1 antibody
United States Biological
54 antibodies
Sigma-Aldrich
5 antibodies
Abbexa
3 antibodies
EMD Millipore
2 antibodies
GenWay
1 antibody