NOTCH4

gene product
INT3
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]
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303 antibodies from 31 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
7 antibodies
antibodies-online
90 antibodies
NovoPro Bioscience Inc.
3 antibodies
GeneTex
4 antibodies
LifeSpan BioSciences, Inc.
88 antibodies
Aviva Systems Biology
4 antibodies
Biorbyt
18 antibodies
Invitrogen Antibodies
3 antibodies
R&D Systems
2 antibodies
Boster Biological Technology
2 antibodies
Cell Signaling Technology, Inc
1 antibody
Creative Diagnostics
7 antibodies
OriGene
3 antibodies
Creative Biolabs
24 antibodies
NSJ Bioreagents
2 antibodies
Abgent
3 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Bioworld Technology, Inc
1 antibody
RayBiotech, Inc.
1 antibody
Miltenyi Biotec
3 antibodies
St John's Laboratory
3 antibodies
ProSci
2 antibodies
Abiocode, Inc.
1 antibody
MyBioSource
6 antibodies
RabMAbs
1 antibody
United States Biological
15 antibodies
EMD Millipore
2 antibodies
Sigma-Aldrich
3 antibodies
Everest Biotech
1 antibody
GenWay
1 antibody
Abnova Corporation
1 antibody