MAP3K2

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

Description

Mitogen-activated protein kinase kinase kinase 2

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (127298730 - 127388465)

Ensembl ID

ENSG00000169967  (ver. 103.38)

Orthologs

Mouse Map3k2: ENSMUSG00000024383

UniProt

Q9Y2U5

neXtProt

NX_Q9Y2U5

Human splice variants
Mouse splice variants

Protein structure