PYHIN1

The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Description

Pyrin and HIN domain family member 1

Tissue specificity

Tissue enriched (lymphoid tissue)

Subcell location

Nucleoplasm, Nucleoli

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (158930796 - 158977059)

Ensembl ID

ENSG00000163564  (ver. 103.38)

Orthologs

-

UniProt

Q6K0P9

neXtProt

NX_Q6K0P9

Human splice variants

Protein structure