COL4A1

gene product
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
756 antibodies from 34 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
79 antibodies
GeneTex
8 antibodies
antibodies-online
249 antibodies
Rockland Immunochemicals, Inc.
6 antibodies
Abnova Corporation
3 antibodies
Acris Antibodies GmbH
31 antibodies
Biorbyt
59 antibodies
Affinity Biosciences
1 antibody
LifeSpan BioSciences, Inc.
52 antibodies
Invitrogen Antibodies
3 antibodies
NovoPro Bioscience Inc.
2 antibodies
Aviva Systems Biology
10 antibodies
Abgent
1 antibody
OriGene
30 antibodies
NSJ Bioreagents
5 antibodies
Boster Biological Technology
5 antibodies
Arigo
2 antibodies
Bioworld Technology, Inc
1 antibody
St John's Laboratory
10 antibodies
ProSci
2 antibodies
GenWay
16 antibodies
Creative Biolabs
57 antibodies
Abbkine Scientific Co.Ltd.
9 antibodies
Proteintech Group
1 antibody
Creative Diagnostics
18 antibodies
R&D Systems
2 antibodies
RabMAbs
1 antibody
MyBioSource
10 antibodies
EMD Millipore
6 antibodies
United States Biological
28 antibodies
Abbexa
6 antibodies
YO Proteins AB
3 antibodies
eBioscience, An Affymetrix Company
4 antibodies