CFB

gene product
BF, BFD, H2-Bf
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Antibodypedia Validation Initiative

Validation method

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
496 antibodies from 32 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeAVIWBELICCIPIHCFC
Novus Biologicals
10 antibodies
GeneTex
8 antibodies
antibodies-online
130 antibodies
Biorbyt
17 antibodies
Invitrogen Antibodies
10 antibodies
Atlas Antibodies
2 antibodies
Acris Antibodies GmbH
15 antibodies
OriGene
15 antibodies
R&D Systems
3 antibodies
Aviva Systems Biology
8 antibodies
NovoPro Bioscience Inc.
2 antibodies
Proteintech Group
2 antibodies
LifeSpan BioSciences, Inc.
126 antibodies
Abnova Corporation
7 antibodies
Abgent
2 antibodies
NSJ Bioreagents
1 antibody
Santa Cruz Biotechnology
1 antibody
ProSci
2 antibodies
Bioworld Technology, Inc
1 antibody
Boster Biological Technology
2 antibodies
Sigma-Aldrich
2 antibodies
Creative Diagnostics
10 antibodies
MyBioSource
23 antibodies
Creative Biolabs
19 antibodies
GenWay
4 antibodies
United States Biological
63 antibodies
Abbexa
3 antibodies
Abbiotec
3 antibodies
Abbkine
1 antibody
St John's Laboratory
1 antibody
RabMAbs
2 antibodies
RayBiotech, Inc.
1 antibody