SPN

gene product
CD43, GPL115, LSN
This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome. [provided by RefSeq, Sep 2017]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
2081 antibodies from 43 providers.

Antibody properties

General

Applications

or Cancel
Antibody
NSJ Bioreagents
18 antibodies
Novus Biologicals
199 antibodies
GeneTex
25 antibodies
Abgent
4 antibodies
antibodies-online
837 antibodies
Antibodies.com
5 antibodies
Acris Antibodies GmbH
47 antibodies
OriGene
103 antibodies
Abnova Corporation
42 antibodies
R&D Systems
12 antibodies
LifeSpan BioSciences, Inc.
308 antibodies
Invitrogen Antibodies
23 antibodies
ABEOMICS Inc.
1 antibody
Biorbyt
57 antibodies
NovoPro Bioscience Inc.
2 antibodies
Boster Biological Technology
2 antibodies
Proteintech Group
2 antibodies
Bethyl Laboratories
1 antibody
Aviva Systems Biology
20 antibodies
Atlas Antibodies
1 antibody
Bioworld Technology, Inc
1 antibody
Spring Bioscience
8 antibodies
Creative Biolabs
79 antibodies
ProSci
6 antibodies
St John's Laboratory
2 antibodies
United States Biological
94 antibodies
MyBioSource
8 antibodies
GenWay
18 antibodies
BioLegend
10 antibodies
Abbexa
13 antibodies
Creative Diagnostics
15 antibodies
Miltenyi Biotec
62 antibodies
Absolute Antibody
5 antibodies
STEMCELL Technologies Inc
5 antibodies
RayBiotech, Inc.
6 antibodies
Abiocode, Inc.
1 antibody
eBioscience, An Affymetrix Company
5 antibodies
Nordic BioSite
2 antibodies
Sigma-Aldrich
2 antibodies
BioLegend (formerly Covance Antibody Products)
1 antibody
EMD Millipore
1 antibody