CD27

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]

Description

CD27 molecule

Tissue specificity

Tissue enriched (lymphoid tissue)

Predicted location

Membrane

Protein family

Cancer-related genes
CD markers
Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

12 (6444955 - 6451718)

Ensembl ID

ENSG00000139193  (ver. 103.38)

Orthologs

Mouse Cd27: ENSMUSG00000030336

UniProt

P26842

neXtProt

NX_P26842

Human splice variants
Mouse splice variants

Protein structure