SELPLG

gene product
CD162, PSGL-1
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
1096 antibodies from 38 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
155 antibodies
R&D Systems
26 antibodies
antibodies-online
326 antibodies
Invitrogen Antibodies
26 antibodies
BioLegend
19 antibodies
LifeSpan BioSciences, Inc.
177 antibodies
OriGene
12 antibodies
GeneTex
14 antibodies
Boster Biological Technology
2 antibodies
Abnova Corporation
9 antibodies
Bioworld Technology, Inc
1 antibody
Acris Antibodies GmbH
16 antibodies
NovoPro Bioscience Inc.
9 antibodies
Affinity Biosciences
1 antibody
Proteintech Group
1 antibody
Biorbyt
30 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Creative Biolabs
90 antibodies
Antibodies.com
5 antibodies
St John's Laboratory
2 antibodies
NSJ Bioreagents
1 antibody
Aviva Systems Biology
10 antibodies
RabMAbs
2 antibodies
Arigo
4 antibodies
ProSci
3 antibodies
United States Biological
43 antibodies
eBioscience, An Affymetrix Company
9 antibodies
EMD Millipore
2 antibodies
Creative Diagnostics
7 antibodies
Miltenyi Biotec
31 antibodies
Abgent
5 antibodies
GenWay
9 antibodies
MyBioSource
4 antibodies
Abbexa
5 antibodies
RayBiotech, Inc.
4 antibodies
Leading Biology
4 antibodies
Sino Biological Inc.
2 antibodies