Tissue expression
Cell line expression
Protein structure
ARNT2
Aryl hydrocarbon receptor nuclear translocator 2bHLHe1, KIAA0307
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013]
Top validated antibodies |
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Atlas Antibodies | HPA001056 | 1 references | Polyclonal |
ICC
IHC |
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Proteintech Group | 12810-1-AP | 1 references | Polyclonal |
WB
EL
IHC
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LSBio | LS-C380446 | Polyclonal |
WB
EL
IHC
|
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Santa Cruz Biotechnology | sc-5581 | 2 references | Polyclonal |
WB
IHC |
|
Biorbyt | orb4569 | Polyclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
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Recommended by provider