DAB2

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Description

DAB adaptor protein 2

Tissue specificity

Tissue enhanced (kidney, placenta)

Subcell location

Nucleoli fibrillar center, Vesicles, Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (39371675 - 39462300)

Ensembl ID

ENSG00000153071  (ver. 103.38)

Orthologs

Mouse Dab2: ENSMUSG00000022150

UniProt

P98082

neXtProt

NX_P98082

Human splice variants
Mouse splice variants

Protein structure