Tissue expression
Cell line expression

FURIN

gene product
FUR, PACE, PCSK3, SPC1 
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. Like other members of this convertase family, the product of this gene specifically cleaves substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140, and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
More gene data

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463 antibodies from 39 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
9 antibodies
Novus Biologicals
40 antibodies
Proteintech Group
2 antibodies
antibodies-online
141 antibodies
St John's Laboratory
9 antibodies
NovoPro Bioscience Inc.
4 antibodies
Enzo Life Sciences
6 antibodies
R&D Systems
12 antibodies
Boster Biological Technology
4 antibodies
Cusabio Biotech Co., Ltd
5 antibodies
Wuhan Fine Biotech Co., Ltd.
2 antibodies
HUABIO Research
1 antibody
Santa Cruz Biotechnology
1 antibody
LifeSpan BioSciences, Inc.
93 antibodies
Biorbyt
17 antibodies
GeneTex
4 antibodies
Abnova Corporation
2 antibodies
OriGene
3 antibodies
Acris Antibodies GmbH
6 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Antibodies.com
1 antibody
Bioworld Technology, Inc
1 antibody
Everest Biotech
3 antibodies
NSJ Bioreagents
3 antibodies
Creative Diagnostics
8 antibodies
ABEOMICS Inc.
2 antibodies
Abgent
4 antibodies
Arigo
1 antibody
Aviva Systems Biology
1 antibody
Abbexa
13 antibodies
MyBioSource
6 antibodies
ProSci
2 antibodies
Creative Biolabs
26 antibodies
Leading Biology
4 antibodies
United States Biological
4 antibodies
RayBiotech, Inc.
2 antibodies
MilliporeSigma / Merck KGaA
2 antibodies
EMD Millipore
2 antibodies