Tissue expression
Cell line expression
Protein structure
FURIN
Furin, paired basic amino acid cleaving enzymeFUR, PACE, PCSK3, SPC1
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. Like other members of this convertase family, the product of this gene specifically cleaves substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140, and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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Invitrogen Antibodies | PA1-062 | 51 references | Polyclonal |
WB
ICC
IP
FC
OA
|
|
Novus Biologicals | NB100-1903 | Polyclonal |
WB
ICC
IP
IHC
FC
BN |
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Proteintech Group | 18413-1-AP | 9 references | Polyclonal |
WB
EL
IP
IHC |
|
antibodies-online | ABIN151400 | Polyclonal |
WB
ICC
IP
IHC
FC
BN |
||
St John's Laboratory | STJ29581 | Polyclonal |
WB
ICC
IP
IHC
ChIP
|
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