GREM2

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]

Description

Gremlin 2, DAN family BMP antagonist

Tissue specificity

Tissue enhanced (gallbladder, liver)

Predicted location

Secreted to blood

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

1 (240489573 - 240612155)

Ensembl ID

ENSG00000180875  (ver. 103.38)

Orthologs

Mouse Grem2: ENSMUSG00000050069

UniProt

Q9H772

neXtProt

NX_Q9H772

Human splice variants
Mouse splice variants

Protein structure