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NRAS
NRAS proto-oncogene, GTPaseN-ras
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
Top validated antibodies |
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| Invitrogen Antibodies |  MA1-012 |
13 references | Monoclonal |
WB
ICC
IP
IHC
FC
OA
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| Proteintech Group | 10724-1-AP |
11 references | Polyclonal |
WB
EL
ICC
IHC
FC
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| Novus Biologicals | NB100-94887 |
1 references | Polyclonal |
WB
EL
IHC
FC
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| antibodies-online | ABIN2485488 |
6 references | Polyclonal |
WB
ICC
IHC
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| NovoPro Bioscience Inc. | 113271 |
Polyclonal |
WB
EL
ICC
IHC
FC
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