Tissue expression
Cell line expression
Protein structure
NECTIN1
Nectin cell adhesion molecule 1CD111, CLPED1, ED4, HIgR, HVEC, OFC7, PRR, PRR1, PVRL1, PVRR1, SK-12
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]
Top validated antibodies |
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OriGene | TA328659 | 1 references | Polyclonal |
WB
ICC
IHC
FC |
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Proteintech Group | 24713-1-AP | 2 references | Polyclonal |
WB
EL
ICC
IHC |
|
Invitrogen Antibodies | 37-5900 | 8 references | Monoclonal |
WB
EL
IP
FC
OA
|
|
GeneTex | GTX54843 | Polyclonal |
WB
ICC
IHC
FC |
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Novus Biologicals | NBP2-54643-0.1mg | Monoclonal |
WB
ICC
IP
IHC
FC
|
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Supportive data in Antibodypedia
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Recommended by provider