Tissue expression
Cell line expression
Protein structure
DUSP6
Dual specificity phosphatase 6MKP-3, PYST1
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
Top validated antibodies |
|||||
Novus Biologicals | H00001848-M01 | 4 references | Monoclonal |
WB
EL
ICC
IHC
BN
|
|
Abnova Corporation | H00001848-M01 | 3 references | Monoclonal |
WB
EL
ICC
IHC |
|
Boster Biological Technology | M02157 | 1 references | Monoclonal |
WB
ICC
IP
IHC
FC
|
|
NSJ Bioreagents | RQ6707 | Polyclonal |
WB
EL
ICC
IHC
FC
|
||
antibodies-online | ABIN560670 | 3 references | Monoclonal |
WB
EL
ICC
IHC |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider