DUSP6

gene product
MKP-3, PYST1
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
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493 antibodies from 34 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Abnova Corporation
7 antibodies
Novus Biologicals
7 antibodies
antibodies-online
173 antibodies
OriGene
8 antibodies
Acris Antibodies GmbH
4 antibodies
Boster Biological Technology
1 antibody
LifeSpan BioSciences, Inc.
82 antibodies
NovoPro Bioscience Inc.
4 antibodies
Affinity Biosciences
4 antibodies
Abgent
5 antibodies
St John's Laboratory
6 antibodies
Biorbyt
31 antibodies
Aviva Systems Biology
5 antibodies
GeneTex
5 antibodies
NSJ Bioreagents
3 antibodies
R&D Systems
1 antibody
Santa Cruz Biotechnology
1 antibody
Invitrogen Antibodies
8 antibodies
Bioworld Technology, Inc
2 antibodies
RabMAbs
3 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
Antibodies.com
1 antibody
Proteintech Group
1 antibody
ProSci
5 antibodies
Creative Biolabs
3 antibodies
MyBioSource
15 antibodies
Creative Diagnostics
7 antibodies
RayBiotech, Inc.
2 antibodies
Cell Signaling Technology, Inc
2 antibodies
Signalway Antibody LLC
2 antibodies
United States Biological
88 antibodies
Abbexa
1 antibody
Sigma-Aldrich
3 antibodies
Everest Biotech
1 antibody