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TNNI3
Troponin I3, cardiac typeCMD2A, CMH7, TNNC1
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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| Novus Biologicals |  NB110-2546 |
2 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
ChIP
OA
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| Proteintech Group | 21652-1-AP |
34 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Abnova Corporation | H00007137-M04 |
1 references | Monoclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | MA1-20112 |
8 references | Monoclonal |
WB
EL
IP
IHC
OA
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| LSBio | LS-C352958 |
Polyclonal |
WB
ICC
IHC
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