Tissue expression
Cell line expression

CHCHD2

gene product
C7orf17, MIX17B, MNRR1 
The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
More gene data

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149 antibodies from 26 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
4 antibodies
Invitrogen Antibodies
10 antibodies
Biorbyt
12 antibodies
antibodies-online
51 antibodies
NovoPro Bioscience Inc.
2 antibodies
Abnova Corporation
3 antibodies
Atlas Antibodies
2 antibodies
Abgent
1 antibody
Arigo
1 antibody
GeneTex
1 antibody
OriGene
1 antibody
Wuhan Fine Biotech Co., Ltd.
1 antibody
LifeSpan BioSciences, Inc.
17 antibodies
Novus Biologicals
4 antibodies
Aviva Systems Biology
1 antibody
Cusabio Biotech Co., Ltd
1 antibody
ProSci
1 antibody
Affinity Biosciences
1 antibody
MyBioSource
3 antibodies
United States Biological
13 antibodies
Leading Biology
1 antibody
MilliporeSigma / Merck KGaA
1 antibody
Creative Diagnostics
1 antibody
Abbexa
2 antibodies
Creative Biolabs
2 antibodies