Tissue expression
Cell line expression
EDNRB
gene productETB, HSCR, HSCR2
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Featured antibodies
![]() |
![]() |
0 references | Polyclonal |
WB
ICC IHC
FC |