Tissue expression
Cell line expression
Protein structure
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor 6alpha-PIX, alphaPIX, Cool-2, Cool2, KIAA0006, MRX46, αPix
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Novus Biologicals | ![]() |
1 references | Monoclonal |
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Abnova Corporation | ![]() |
Monoclonal |
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Atlas Antibodies | ![]() |
1 references | Polyclonal |
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antibodies-online | ![]() |
Monoclonal |
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Invitrogen Antibodies | ![]() |
Polyclonal |
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