ARHGEF6

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008]

Description

Rac/Cdc42 guanine nucleotide exchange factor 6

Protein family

Cancer-related genes, Disease related genes, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

X:q26.3 (136665547 - 136782088)

Ensembl ID

ENSG00000129675  (ver. 84.38)

Orthologs

Mouse Arhgef6: ENSMUSG00000031133

UniProt

Q15052

neXtProt

NX_Q15052

Human splice variants
Mouse splice variants