ARHGEF6

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]

Description

Rac/Cdc42 guanine nucleotide exchange factor 6

Protein family

Cancer-related genes, Disease related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

X:q26.3 (136665547 - 136780932)

Ensembl ID

ENSG00000129675  (ver. 98.38)

Orthologs

Mouse Arhgef6: ENSMUSG00000031133

UniProt

Q15052

neXtProt

NX_Q15052

Human splice variants
Mouse splice variants