PFKFB1

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

Description

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Tissue specificity

Group enriched (adipose tissue, liver, skeletal muscle, tongue)

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

X (54932961 - 54998534)

Ensembl ID

ENSG00000158571  (ver. 103.38)

Orthologs

Mouse Pfkfb1: ENSMUSG00000025271

UniProt

P16118

neXtProt

NX_P16118

Human splice variants
Mouse splice variants

Protein structure