DACT1

The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Description

Dishevelled binding antagonist of beta catenin 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

14 (58633967 - 58648321)

Ensembl ID

ENSG00000165617  (ver. 103.38)

Orthologs

Mouse Dact1: ENSMUSG00000044548

UniProt

Q9NYF0

neXtProt

NX_Q9NYF0

Human splice variants
Mouse splice variants

Protein structure