Tissue expression
Cell line expression

LIG4

gene product
 
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
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320 antibodies from 32 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
4 antibodies
Proteintech Group
2 antibodies
Novus Biologicals
8 antibodies
antibodies-online
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Invitrogen Antibodies
16 antibodies
LifeSpan BioSciences, Inc.
23 antibodies
Affinity Biosciences
3 antibodies
Cusabio Biotech Co., Ltd
5 antibodies
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9 antibodies
Biorbyt
17 antibodies
Atlas Antibodies
2 antibodies
Boster Biological Technology
4 antibodies
OriGene
4 antibodies
Bioworld Technology, Inc
2 antibodies
St John's Laboratory
6 antibodies
HUABIO Research
1 antibody
NovoPro Bioscience Inc.
1 antibody
Wuhan Fine Biotech Co., Ltd.
1 antibody
Aviva Systems Biology
3 antibodies
Abbkine Scientific Co.Ltd.
3 antibodies
Acris Antibodies GmbH
1 antibody
MyBioSource
9 antibodies
Abbexa
9 antibodies
Abgent
2 antibodies
Arigo
1 antibody
United States Biological
36 antibodies
Creative Diagnostics
5 antibodies
Creative Biolabs
12 antibodies
Cell Signaling Technology, Inc
1 antibody
RabMAbs
1 antibody
MilliporeSigma / Merck KGaA
5 antibodies