IKBKE

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]). [supplied by OMIM, Oct 2009]

Description

inhibitor of nuclear factor kappa B kinase subunit epsilon

Protein family

Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

1:q32.1 (206470476 - 206496889)

Ensembl ID

ENSG00000263528  (ver. 98.38)

Orthologs

Mouse Ikbke: ENSMUSG00000042349

UniProt

Q14164

neXtProt

NX_Q14164

Human splice variants
Mouse splice variants