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PDE6B
Phosphodiesterase 6BCSNB3, CSNBAD2, PDEB, rd1, RP40
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Top validated antibodies |
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| Invitrogen Antibodies |  PA1-722 |
22 references | Polyclonal |
WB
ICC
IHC
OA
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| Proteintech Group | 22063-1-AP |
5 references | Polyclonal |
WB
EL
ICC
IP
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| NSJ Bioreagents | RQ5910 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Boster Biological Technology | A02659-1 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| antibodies-online | ABIN267359 |
1 references | Polyclonal |
WB
ICC
IHC
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