IL1RN

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Description

interleukin 1 receptor antagonist

Protein family

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

2:q14.1 (113107214 - 113134016)

Ensembl ID

ENSG00000136689  (ver. 84.38)

Orthologs

Mouse Il1rn: ENSMUSG00000026981

UniProt

P18510

neXtProt

NX_P18510

Human splice variants
Mouse splice variants