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Protein structure
IL1RN
Interleukin 1 receptor antagonistICIL-1RA, IL-1RN, IL1F3, IL1RA, IRAP, MGC10430
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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| Novus Biologicals |  AF-280-NA |
10 references | Polyclonal |
WB
IHC
BN
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| R&D Systems | AF-280-NA |
10 references | Polyclonal |
WB
IHC
BN
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| Proteintech Group | 10844-1-AP |
4 references | Polyclonal |
WB
EL
IHC
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| antibodies-online | ABIN2840788 |
1 references | Polyclonal |
WB
ICC
IHC
FC
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| Abcepta | AP6503a |
Polyclonal |
WB
ICC
IHC
FC
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