KLKB1

This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Description

Kallikrein B1

Tissue specificity

Tissue enriched (liver)

Predicted location

Intracellular, Secreted to blood

Protein family

Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (186208979 - 186258471)

Ensembl ID

ENSG00000164344  (ver. 103.38)

Orthologs

Mouse Klkb1: ENSMUSG00000109764

UniProt

P03952

neXtProt

NX_P03952

Human splice variants
Mouse splice variants

Protein structure