Protein structure
CASP12
Caspase 12 (gene/pseudogene)Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]
Top validated antibodies |
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Invitrogen Antibodies | PA5-19963 | 2 references | Polyclonal |
WB
ICC
IHC
OA |
|
antibodies-online | ABIN951051 | 3 references | Polyclonal |
WB
ICC
IHC
FC |
|
Novus Biologicals | NBP1-76801 | 3 references | Polyclonal |
WB
EL
ICC
IHC |
|
Acris Antibodies GmbH | AM20297AF-N | Monoclonal |
WB
ICC
IP
IHC |
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Abgent | AP12027C | Polyclonal |
WB
ICC
IHC
FC |
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