Protein structure

CASP12

Caspase 12 (gene/pseudogene)
 
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]
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572 antibodies from 41 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
31 antibodies
antibodies-online
151 antibodies
Novus Biologicals
10 antibodies
Acris Antibodies GmbH
24 antibodies
OriGene
17 antibodies
Abgent
10 antibodies
NSJ Bioreagents
3 antibodies
Abnova Corporation
9 antibodies
Boster Biological Technology
2 antibodies
Arigo
4 antibodies
GeneTex
7 antibodies
Biorbyt
16 antibodies
NovoPro Bioscience Inc.
6 antibodies
ProSci
8 antibodies
Enzo Life Sciences
2 antibodies
Aviva Systems Biology
1 antibody
Affinity Biosciences
1 antibody
St John's Laboratory
3 antibodies
R&D Systems
1 antibody
Bioworld Technology, Inc
1 antibody
Cusabio Biotech Co., Ltd
4 antibodies
Antibodies.com
1 antibody
MyBioSource
10 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Everest Biotech
1 antibody
United States Biological
85 antibodies
ABEOMICS Inc.
2 antibodies
Creative Biolabs
6 antibodies
Creative Diagnostics
6 antibodies
Leading Biology
5 antibodies
Cell Signaling Technology, Inc
2 antibodies
QED Bioscience
2 antibodies
RayBiotech, Inc.
3 antibodies
Abiocode, Inc.
1 antibody
GenWay
3 antibodies
EMD Millipore
2 antibodies
Abbexa
8 antibodies
eBioscience, An Affymetrix Company
2 antibodies
Rockland Immunochemicals, Inc.
7 antibodies