Tissue expression
Cell line expression
Protein structure
MASP1
Mannan binding lectin serine peptidase 1CRARF, MASP, PRSS5
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Top validated antibodies |
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Proteintech Group | 21837-1-AP | Polyclonal |
WB
EL
IHC
|
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R&D Systems | AF1724 | 1 references | Polyclonal |
WB
IP |
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Novus Biologicals | AF1724 | 1 references | Polyclonal |
WB
IP |
|
antibodies-online | ABIN733508 | Polyclonal |
WB
ICC
IHC
|
||
OriGene | AM32981PU-N | Monoclonal |
WB
EL
IP
|
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Enhanced validation
Supportive data in Antibodypedia
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Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider