ARHGEF12

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Description

Rho guanine nucleotide exchange factor 12

Protein family

Cancer-related genes, Disease related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

11:q23.3 (120336413 - 120489937)

Ensembl ID

ENSG00000196914  (ver. 99.38)

Orthologs

Mouse Arhgef12: ENSMUSG00000059495

UniProt

Q9NZN5

neXtProt

NX_Q9NZN5

Human splice variants
Mouse splice variants