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Protein structure
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif 5ADAMTS11, ADMP-2
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]
Top validated antibodies |
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| Invitrogen Antibodies |  PA5-27165 |
3 references | Polyclonal |
WB
IHC
OA
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| Boster Biological Technology | A02802-1 |
16 references | Polyclonal |
WB
EL
IHC
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| Novus Biologicals | NBP2-15286 |
2 references | Polyclonal |
WB
IHC
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| GeneTex | GTX100332 |
1 references | Polyclonal |
WB
IHC
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| Biorbyt | orb5678 |
Polyclonal |
WB
EL
ICC
IHC
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