CLIC3

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]

Description

Chloride intracellular channel 3

Tissue specificity

Group enriched (esophagus, skin , thyroid gland, vagina)

Subcell location

Nuclear bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

9:q34.3 (136994608 - 136996568)

Ensembl ID

ENSG00000169583  (ver. 103.38)

Orthologs

Mouse Clic3: ENSMUSG00000015093

UniProt

O95833

neXtProt

NX_O95833

Human splice variants
Mouse splice variants