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EIF2AK3
Eukaryotic translation initiation factor 2 alpha kinase 3PEK, PERK
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
Top validated antibodies |
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| LSBio |  LS-C353177 |
Polyclonal |
WB
ICC
IP
IHC
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| Proteintech Group | 20582-1-AP |
96 references | Polyclonal |
WB
EL
ICC
IHC
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| Boster Biological Technology | P01992 |
3 references | Polyclonal |
WB
EL
ICC
IHC
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| Novus Biologicals | NBP1-78017 |
Polyclonal |
WB
EL
ICC
IP
IHC
|
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| Invitrogen Antibodies | PA5-79193 |
2 references | Polyclonal |
WB
FC
OA
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