Tissue expression
Cell line expression
Protein structure
IL1B
Interleukin 1 betaIL-1B, IL1-BETA, IL1F2
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020]
Top validated antibodies |
|||||
Novus Biologicals | NB600-633 | 27 references | Polyclonal |
WB
EL
ICC
IP
IHC
IEM |
|
GeneTex | GTX74034 | 29 references | Polyclonal |
WB
EL
ICC
IHC
FA
|
|
R&D Systems | AF-201-NA | 29 references | Polyclonal |
WB
ICC
IHC
BN |
|
antibodies-online | ABIN1107772 | 2 references | Monoclonal |
WB
EL
ICC
IHC |
|
Abnova Corporation | H00003553-M01 | 1 references | Monoclonal |
WB
EL
ICC
IP |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider