RPS6KA3

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]

Description

ribosomal protein S6 kinase A3

Protein family

Cancer-related genes, Disease related genes, Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Protein evidence (Peptideatlas)

Chromosome

X:p22.12 (20149911 - 20267519)

Ensembl ID

ENSG00000177189  (ver. 99.38)

Orthologs

Mouse Rps6ka3: ENSMUSG00000031309

UniProt

P51812

neXtProt

NX_P51812

Human splice variants
Mouse splice variants