CCND2

gene product
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
779 antibodies from 37 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Invitrogen Antibodies
13 antibodies
Atlas Antibodies
2 antibodies
GeneTex
7 antibodies
OriGene
32 antibodies
Novus Biologicals
27 antibodies
antibodies-online
270 antibodies
Biorbyt
47 antibodies
Abnova Corporation
7 antibodies
LifeSpan BioSciences, Inc.
181 antibodies
Affinity Biosciences
3 antibodies
Proteintech Group
2 antibodies
Bioworld Technology, Inc
1 antibody
St John's Laboratory
6 antibodies
Acris Antibodies GmbH
10 antibodies
NSJ Bioreagents
7 antibodies
Cell Signaling Technology, Inc
1 antibody
Creative Biolabs
27 antibodies
Aviva Systems Biology
5 antibodies
MyBioSource
14 antibodies
Abgent
4 antibodies
Abbiotec
2 antibodies
Creative Diagnostics
4 antibodies
Boster Biological Technology
3 antibodies
Sigma-Aldrich
2 antibodies
Arigo
1 antibody
BioLegend
1 antibody
GenWay
3 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
Abiocode, Inc.
1 antibody
Exalpha Biologicals, Inc.
1 antibody
NovoPro Bioscience Inc.
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
United States Biological
67 antibodies
Enzo Life Sciences
2 antibodies
Leading Biology
4 antibodies
Abbexa
3 antibodies