Tissue expression
Cell line expression
Protein structure

CCND2

Cyclin D2
 
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
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906 antibodies from 39 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
50 antibodies
Atlas Antibodies
2 antibodies
GeneTex
7 antibodies
OriGene
32 antibodies
Proteintech Group
2 antibodies
Biorbyt
94 antibodies
antibodies-online
270 antibodies
Abnova Corporation
7 antibodies
Novus Biologicals
27 antibodies
Cusabio Biotech Co., Ltd
12 antibodies
Affinity Biosciences
3 antibodies
FineTest Biotech
1 antibody
Bioworld Technology, Inc
1 antibody
Boster Biological Technology
3 antibodies
St John's Laboratory
5 antibodies
Exalpha Biologicals, Inc.
1 antibody
Acris Antibodies GmbH
10 antibodies
NSJ Bioreagents
7 antibodies
Cell Signaling Technology, Inc
1 antibody
Creative Biolabs
29 antibodies
Aviva Systems Biology
5 antibodies
MyBioSource
14 antibodies
Abgent
4 antibodies
Abbiotec
2 antibodies
Creative Diagnostics
4 antibodies
MilliporeSigma / Merck KGaA
4 antibodies
Arigo
1 antibody
BioLegend
1 antibody
Abbexa
30 antibodies
GenWay
3 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
Abiocode, Inc.
1 antibody
NovoPro Bioscience Inc.
1 antibody
United States Biological
67 antibodies
Enzo Life Sciences
2 antibodies
Leading Biology
4 antibodies
Rockland Immunochemicals, Inc.
1 antibody